학술논문
Breakthrough zygomycosis on posaconazole prophylaxis after allogeneic stem cell transplantation.
Document Type
Article
Author
Source
Subject
*STEM cell transplantation
*GRAFT versus host disease
*ANTIFUNGAL agents
*PNEUMONIA
*AMPHOTERICIN B
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Language
ISSN
1398-2273
Abstract
S. Mousset, G. Bug, W.J. Heinz, K. Tintelnot, V. Rickerts. Breakthrough zygomycosis on posaconazole prophylaxis after allogeneic stem cell transplantation. Transpl Infect Dis 2010: 12: 261–264. All rights reserved Antifungal prophylaxis with posaconazole (POS) has been shown to decrease the mortality associated with invasive fungal infections in high-risk patients. We report on a patient, with severe graft-versus-host disease after allogeneic stem cell transplantation, who developed proven pneumonia due to Rhizopus microsporus after 40 days of POS prophylaxis (fasting serum levels: 691–904 ng/mL). Despite combination treatment with liposomal amphotericin B and POS for 39 days, the patient died from pulmonary hemorrhage. This case highlights the need for continued awareness of breakthrough zygomycosis in patients receiving POS. [ABSTRACT FROM AUTHOR]