학술논문
A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Document Type
Article
Author
Taira, Makiko; Imamura, Minako; Takahashi, Atsushi; Kamatani, Yoichiro; Yamauchi, Toshimasa; Araki, Shin-ichi; Tanaka, Nobue; van Zuydam, Natalie R.; Ahlqvist, Emma; Toyoda, Masao; Umezono, Tomoya; Kawai, Koichi; Imanishi, Masahito; Watada, Hirotaka; Suzuki, Daisuke; Maegawa, Hiroshi; Babazono, Tetsuya; Kaku, Kohei; Kawamori, Ryuzo; null, null
Source
Subject
*DIABETIC nephropathies
*TYPE 2 diabetes
*SINGLE nucleotide polymorphisms
*DATA analysis
*META-analysis
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Language
ISSN
1932-6203
Abstract
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 × 10−4) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 × 10−10. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 × 10−10). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. [ABSTRACT FROM AUTHOR]