학술논문
Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.
Document Type
Article
Author
Source
Subject
*EMBRYONIC stem cells
*FETAL growth disorders
*INSULIN-like growth factor-binding proteins
*PHYSIOLOGY
*GENETICS
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Language
ISSN
0028-0836
Abstract
Reports on experiments which show that overexpression of fetal insulin-like growth factor (Igf2) in chimeras made with transgenic embryonic stem (ES) cells leads to the development of most of the Beckwith-Wiedemann syndrome (BWS) phenotypes in a fashion dependent on Igf2 mRNA dosage. Methods used to establish lgf2 transgenic ES cell lines; Findings; Discussion of results.