학술논문
Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis.
Document Type
Article
Author
Rohrbeck, Matthias; Hoerr, Verena; Piccini, Ilaria; Greber, Boris; Schulte, Jan Sebastian; Hübner, Sara-Sophie; Jeworutzki, Elena; Theiss, Carsten; Matschke, Veronika; Stypmann, Jörg; Unger, Andreas; Ho, Huyen Tran; Disse, Paul; Strutz-Seebohm, Nathalie; Faber, Cornelius; Müller, Frank Ulrich; Ludwig, Stephan; Rescher, Ursula; Linke, Wolfgang A.; Klingel, Karin
Source
Subject
*HEART diseases
*MICE
*MYOCARDITIS
*TRANSGENIC mice
*HEART failure
*RNA viruses
*GENE expression
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Language
ISSN
2073-4409
Abstract
Viral myocarditis is pathologically associated with RNA viruses such as coxsackievirus B3 (CVB3), or more recently, with SARS-CoV-2, but despite intensive research, clinically proven treatment is limited. Here, by use of a transgenic mouse strain (TG) containing a CVB3ΔVP0 genome we unravel virus-mediated cardiac pathophysiological processes in vivo and in vitro. Cardiac function, pathologic ECG alterations, calcium homeostasis, intracellular organization and gene expression were significantly altered in transgenic mice. A marked alteration of mitochondrial structure and gene expression indicates mitochondrial impairment potentially contributing to cardiac contractile dysfunction. An extended picture on viral myocarditis emerges that may help to develop new treatment strategies and to counter cardiac failure. [ABSTRACT FROM AUTHOR]