학술논문
Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database).
Document Type
Article
Author
Source
Subject
*BRONCHIECTASIS
*DATABASES
*MEDICAL information storage & retrieval systems
*ADRENOCORTICAL hormones
*DISEASE exacerbation
*STEROIDS
*MORTALITY
*CARDIOVASCULAR diseases
*PHENOMENOLOGICAL biology
*COMPUTED tomography
*REPORTING of diseases
*DESCRIPTIVE statistics
*RESPIRATORY diseases
*SPUTUM
*LONGITUDINAL method
*PSEUDOMONAS diseases
*ODDS ratio
*RESEARCH
*OBSTRUCTIVE lung diseases
*INTENSIVE care units
*COMPARATIVE studies
*COUGH
*DYSPNEA
*MICROBIOLOGY
*CONFIDENCE intervals
*CACHEXIA
*COMORBIDITY
*CYSTIC fibrosis
*TUBERCULOSIS
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Language
ISSN
2146-3123
Abstract
Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry-based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in Türkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in Türkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non-cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 ± 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research [ABSTRACT FROM AUTHOR]