학술논문
Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms.
Document Type
Article
Author
Source
Subject
*PULMONARY hypertension
*IRON deficiency
*PULMONARY artery
*CARDIOVASCULAR diseases
*HEART failure
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Language
ISSN
2073-4409
Abstract
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH. [ABSTRACT FROM AUTHOR]