학술논문
Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments.
Document Type
Article
Author
Source
Subject
*ANTIBACTERIAL agents
*CAFFEINE
*BACILLUS cereus
*METHYL formate
*STAPHYLOCOCCUS aureus
*
*
*
*
Language
ISSN
0009-3130
Abstract
Cross-coupling of 8-bromocaffeine, 8-bromo-1-butyltheobromine, or 8-bromo-7-butyltheophylline with α-, β-, or ω-amino-acid methyl or t-butyl ester hydrochlorides in toluene in the presence of the catalytic system Pd(OAc)2·XantPhos and Cs2CO3 with microwave activation led to the formation of xanthine derivatives containing amino-acid fragments in the C-8 position. The antibacterial activity against Staphylococcus aureus and Bacillus cereus was studied. [ABSTRACT FROM AUTHOR]