학술논문
Cobalt(iii) catalyzed C-8 selective C–H and C–O coupling of quinoline N-oxide with internal alkynes via C–H activation and oxygen atom transfer.
Document Type
Article
Source
Subject
*COBALT catalysts
*COUPLING reactions (Chemistry)
*REGIOSELECTIVITY (Chemistry)
*QUINOLINE derivatives
*ALKYNES
*OXYGEN atom transfer reactions
*CATALYTIC activity
*FUNCTIONAL groups
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Language
ISSN
1359-7345
Abstract
An efficient, scalable, atom-economical, regio-selective air stable Cp*Co(iii) catalyzed C–H and C–O coupling via a C–H activation/oxygen atom transfer reaction of quinoline N-oxide and an internal alkyne is reported. Such a catalytic transformation is witnessed for the first time with a cobalt catalyst and using N-oxide as a traceless directing group, in contrast to the existing literature. The developed synthetic methodology is straightforward and possesses various functional group tolerances, including heterocycles. [ABSTRACT FROM AUTHOR]