부산대학교 도서관

Background No articles have ever addressed the relationship of BMI with the location of disease in pediatric vitiligo patients. Objective We aimed to explore the relationship between birthweight, reported BMI classifications, and pediatric vitiligo disease characteristics. Methods: We explored 232 consecutive pediatric vitiligo patients. Patients' parents self-reported height, weight, and disease localization. The body mass index classifications were divided into underweight for body mass index (BMI) <18.5, normal for BMI of 18.5 or greater and <25, and overweight for a BMI of 25. Results: Exploring birthweight and age of onset, there was a trend towards decreasing median age of onset with weight increases, but it is not statistically significant when we group the patients by BMI class. There is a trend towards older age for children with higher BMI classes (p-value = 0.06). For kids under the age of 12, duration of disease was 4.6 years, vs. 7.7 years for kids over the age of 12 years (p<0.001). When further broken down into kids under 6 years, >6 and less than 12 years, >12 years, and less than 14 years, and 14-17 years, years of disease jumped from 1.3 to 4, to 6.6, and to 7.5 years respectively, demonstrating increased years of disease burden (P<0.001). There is a positive trend in locations and age when looked at for self-reported BSA of 1-25% vs. >25%: (p-value = 0.044). Wrists, hands, hips, legs, ankles, and feet were statistically more likely to be involved by 14-17 years, over 0-6 years (p<0.05 for each site). BSA was 1-25% in 79% of kids under 12 years of age and 75% for kids> 12 years of age. For those with a BSA of 26%+ all anatomical regions explored were statistically significant (p<0.05) other than the specific locations of the scalp, eyelids, lips or mouth. Limitations The cohort does not address long-term weight fluctuations. There are some limitations to self-reported data. Conclusion: and Relevance Long-term disease in children and adolescents is associated with increasing years of disease burden and extension of disease to highly visible acral locations. BMI was not directly associated with disease extent in this cohort. [ABSTRACT FROM AUTHOR]