학술논문
Synthesis of All Stereoisomers of 1-(4-Methoxyphenyl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide.
Document Type
Article
Source
Subject
*STEREOISOMERS
*CARBOXAMIDES
*ORGANIC synthesis
*AMIDATION
*METHYL formate
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Language
ISSN
1422-8599
Abstract
In this study, all four stereoisomers of tryptoline or tetrahydro-β-carboline were synthesized in high yields by the catalyst-free amidation of methyl ester using methylamine under mild conditions. All isomers of the obtained amide and the precursor methyl ester were subjected to cell viability measurements on HeLa cells. The results indicated that the stereochemistry of the derivatives is clearly related to cell viability. [ABSTRACT FROM AUTHOR]