학술논문
Bioisosteric Exchange of C.
Document Type
Article
Author
Source
Subject
*BIOISOSTERES
*CHEMICAL synthesis
*ANTIFUNGAL agents
*BIOLOGICAL research
*ALIPHATIC compounds
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*
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*
Language
ISSN
1433-7851
Abstract
Asymmetric synthesis and initial biological studies of two analogues of a naturally occurring chlorinated antifungal agent, atpenin A5, are described. These analogues were selected on the basis of Cl→CH3 or H3C→Cl exchanges in the side-chain of atpenin A5. The interchange of chloro and methyl substituents led to complex II inhibitors with equal IC50 values. This suggests that Cl↔Me bioisosteric exchange can be realized in aliphatic settings. [ABSTRACT FROM AUTHOR]