학술논문
MAGUKs are essential, but redundant, in long-term potentiation.
Document Type
Article
Author
Source
Subject
*LONG-term potentiation
*NEURAL transmission
*SCAFFOLD proteins
*AMPA receptors
*TARPAULINS
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Language
ISSN
0027-8424
Abstract
This study presents evidence that the MAGUK family of synaptic scaffolding proteins plays an essential, but redundant, role in longterm potentiation (LTP). The action of PSD-95, but not that of SAP102, requires the binding to the transsynaptic adhesion protein ADAM22, which is required for nanocolumn stabilization. Based on these and previous results, we propose a two-step process in the recruitment of AMPARs during LTP. First, AMPARs, via TARPs, bind to exposed PSD-95 in the PSD. This alone is not adequate to enhance synaptic transmission. Second, the AMPAR/TARP/PSD-95 complex is stabilized in the nanocolumn by binding to ADAM22. A second, ADAM22-independent pathway is proposed for SAP102. [ABSTRACT FROM AUTHOR]