학술논문
Serum sphingosine‐1‐phosphate is elevated in atopic dermatitis and associated with severity.
Document Type
Article
Author
Source
Subject
*ECZEMA
*ATOPIC dermatitis
*SPHINGOSINE-1-phosphate
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Language
ISSN
0105-4538
Abstract
The severity scores for AD and serum concentrations of TARC and interleukin-22 in high-S1P-AD group were higher compared with the normal-S1P-AD subgroup (Table 1). To investigate possible distinguishing phenotypic characteristics of AD in patients with very high serum S1P levels, two subgroups of AD were defined based on serum S1P levels: a normal-S1P-AD group, in which serum S1P levels fell within the 25th-75th percentiles (513.7-675.7 nM), and a high-S1P-AD group, in which serum S1P levels fell within the 90th-100th percentiles (757.3-956.2 nM). Next, we evaluated the AD severity (EASI, BSA) and serum protein biomarkers (TARC, IL-22) in AD subgroups stratified by serum S1P levels every 10th percentile (E-H). [Extracted from the article]