부산대학교 도서관

I Dear Editor, i Generalized pustular figurate erythema (GPFE) is a distinctive severe cutaneous drug reaction with widespread urticarial or edematous plaques scattered over the entire body that become topped with non-follicular pustules that evolve into erythematous and sometimes atypical targetoid plaques converging into annular and arcuate patterns prominent on the trunk and extremities.1 It has been linked with medications, especially hydroxychloroquine. We describe two COVID-19 patients on hydroxychloroquine who developed this eruption 2 and 3 weeks after the onset of hydroxychloroquine. Purpuric erythematous rash with non-follicular pustules and targetoid lesions on the back. gl In both cases the skin biopsy specimens revealed an acanthotic epidermis with parakeratosis and numerous intracorneal, subcorneal and intraepidermal pustules. [Extracted from the article]