학술논문
Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort.
Document Type
Article
Author
Zhao, Yujia; Ray, Anushree; Broberg, Karin; Kippler, Maria; Lill, Christina M.; Vineis, Paolo; Katzke, Verena A.; Rodriguez‐Barranco, Miguel; Chirlaque, María‐Dolores; Guevara, Marcela; Gómez, Jesús‐Humberto; Hansen, Johnni; Panico, Salvatore; Middleton, Lefkos T.; Masala, Giovanna; Pala, Valeria; Vinagre‐Aragon, Ana; Zibetti, Maurizio; Vermeulen, Roel; Peters, Susan
Source
Subject
Language
ISSN
0885-3185
Abstract
Background: Metals have been postulated as environmental concerns in the etiology of Parkinson's disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective: The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods: A case‐control study was nested in a prospective European cohort, using erythrocyte samples collected before PD diagnosis. Results: Most assessed metals were not associated with PD risk. Cadmium has a suggestive negative association with PD (odds ratio [95% confidence interval] for the highest quartile, 0.70 [0.42–1.17]), which diminished among never smokers. Among current smokers only, lead was associated with decreased PD risk (0.06 [0.01–0.35]), whereas arsenic showed associations toward an increased PD risk (1.85 [0.45–7.93]). Conclusions: We observe no strong evidence to support a role of metals in the development of PD. In particular, smoking may confound the association with tobacco‐derived metals. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]