학술논문
Selenium Protects Neonates against Neurotoxicity from Prenatal Exposure to Manganese.
Document Type
Article
Author
Source
Subject
*NEUROTOXICOLOGY
*PHYSIOLOGICAL effects of selenium
*PRENATAL exposure delayed effects
*PEDIATRIC epidemiology
*ENVIRONMENTAL chemistry
*PUBLIC health research
*PREVENTIVE medicine
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Language
ISSN
1932-6203
Abstract
Manganese (Mn) exposure can affect brain development. Whether Selenium (Se) can protect neonates against neurotoxicity from Mn exposure remains unclear. We investigated this issue in 933 mother-newborn pairs in Shanghai, China, from 2008 through 2009. Umbilical cord serum concentrations of Mn and Se were measured and Neonatal Behavioral Neurological Assessment (NBNA) tests were conducted. The scores <37 were defined as the low NBNA. The median concentrations of cord serum Mn and Se were 4.0 µg/L and 63.1 µg/L, respectively. After adjusting for potential confounders, the interaction between Se and Mn was observed. Cord blood Mn levels had different effects on NBNA scores stratified by different cord blood Se levels. With Se