학술논문
Microwave synthesis of mixed ligand diimine–thiosemicarbazone complexes of ruthenium(ii): biophysical reactivity and cytotoxicityElectronic supplementary information (ESI) available: ESI MS (Fig. S1 and S2) and UV-vis and electrochemistry (Fig. S3 and S4) data. See DOI: 10.1039/b915081a
Document Type
Article
Author
Source
Subject
*METALS in medicine
*METAL complexes
*RUTHENIUM compounds
*THIOSEMICARBAZONES
*MICROWAVES
*IMINES
*CELL-mediated cytotoxicity
*LIGANDS (Chemistry)
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Language
ISSN
1477-9226
Abstract
A novel microwave-assisted synthetic method has been used to synthesise a series of mixed ligand ruthenium(ii) compounds containing diimine as well as bidentate thiosemicarbazone ligands. The compounds contain the diimine 1,10-phenanthroline (phen) or 2,2′-bipyridine (bpy) and the thiosemicarbazone is derived from 9-anthraldehyde. Based on elemental analyses and spectroscopic data, the compounds are best formulated as [(phen)2Ru(thiosemicarbazone)](PF6)2and [(phen)2Ru(thiosemicarbazone)](PF6)2where thiosemicarbazone = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)-methylthiosemicarbazone, and 9-anthraldehyde-N(4)-ethylthiosemicarbazone. Fluorescence competition studies with ethidium bromide, along with viscometric measurements suggests that the complexes bind calf thymus DNA (CTDNA) relatively strongly viaan intercalative mode possibly involving the aromatic rings of the diimine ligands. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines. [ABSTRACT FROM AUTHOR]