학술논문
Spectrum of Anticonvulsant Hypersensitivity Syndrome: Controversy of Treatment.
Document Type
Article
Source
Subject
*ANTICONVULSANTS
*CARBAMAZEPINE
*ALLERGIES
*FEVER
*ADRENOCORTICAL hormones
*ANTIBIOTICS
*
*
*
*
*
Language
ISSN
0883-0738
Abstract
An 18-month-old girl presented with a maculopapular rash 10 daysafter carbamazepine treatment. Initially, she was suspected of hay- biga viral rash owing to associated fever She deteriorated rapidly and wassuspected of having anticonvulsant hypersensitivity syndrome orStevens-Johnson syndrome. She developed features compatible with toxicepidermal necrolysis rapidly over 24 to 36 hours. Carbamazepine was thenstopped. She responded immediately to high-dose intravenous pulsemethylprednisone treatment. We discuss the controversy in the managementof anticonvulsant hypersensitivity syndrome, toxic epidermal necrolysis,or Stevens-Johnson syndrome with high-dose corticosteroids, intravenousimmuoglobulin, and antibiotics. (.1 Child Neurol 2004; 10:619-4323). [ABSTRACT FROM AUTHOR]