부산대학교 도서관

Simple Summary: We report the efficacy and safety of endoscopic resection of residual/recurrent superficial esophageal squamous cell neoplasias (SESCNs) after circumferential radiofrequency ablation (RFA). SESCN patients treated with primary endoscopic submucosal dissection (ESD) served as a control group. Endoscopic mucosal resection failed to remove one residual SESCN. The pathological results of the 16 resected specimens were classified into three groups: high-grade intraepithelial neoplasia (HGIN) without ductal/submucosal glandular involvement (37.5%), HGIN with ductal/submucosal glandular involvement (25.0%), and cancer with muscularis mucosae or deeper involvement (37.5%). These three groups may imply three possible routes in which residual/recurrent SESCNs occurred. Compared with the control group, the study group had similar procedural speed, en bloc resection rate, R0 resection rate, and complication rate. In conclusion, the safety and efficacy of post-RFA ESD were similar to those of primary ESD. We recommend that ESD should be the treatment of choice for residual/recurrent SESCNs after initial RFA. The optimal treatment of residual/recurrent superficial esophageal squamous cell neoplasias (SESCNs) after circumferential radiofrequency (RFA) remains unclear. We aimed to report the efficacy and safety of endoscopic resection (ER) of residual/recurrent SESCNs after RFA. Patients who underwent circumferential RFA with residual/recurrent SESCNs and were treated with ER were retrospectively collected. SESCN patients treated with primary endoscopic submucosal dissection (ESD) served as the control group. Eleven patients who underwent RFA had a total of 17 residual (n = 8) or recurrent (n = 9) SESCNs and were treated for ER. EMR failed to remove one residual SESCN. Of the 16 resected specimens, 10 were high-grade intraepithelial neoplasia (HGIN) and six were cancer. Eight cases had neoplasia extending to esophageal ducts/submucosal glands (SMGs). The pathological results may imply three possible routes in which residual/recurrent SESCNs occurred: HGIN without ductal/SMG involvement (37.5%), HGIN with ductal/SMG involvement (25.0%), and SCC with muscularis mucosae or deeper involvement (37.5%). Compared with the control group, the study group had similar procedural speed, en bloc resection rate, R0 resection rate, and complication rate. In conclusion, the safety and efficacy of post-RFA ESD were similar to those of primary ESD. ESD should be the treatment of choice for residual/recurrent SESCNs after initial RFA. [ABSTRACT FROM AUTHOR]