학술논문
Theme 03 - IN VITRO EXPERIMENTAL MODELS.
Document Type
Article
Author
Source
Subject
*PLURIPOTENT stem cells
*HUMAN stem cells
*AMYOTROPHIC lateral sclerosis
*STEM cells
*CELL death
*FRONTOTEMPORAL lobar degeneration
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*
*
*
*
Language
ISSN
2167-8421
Abstract
An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress. Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. [Extracted from the article]