학술논문
Nitric Oxide-Mediated Vasodilatory Effect Of Atrial Natriuretic Peptide In Forearm Vessels Of Healthy Humans.
Document Type
Article
Author
Source
Subject
*VASODILATION
*NITRIC oxide
*ATRIAL natriuretic peptides
*FOREARM
*BLOOD vessels
*ANGIOTENSIN II
*ENDOTHELIUM
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Language
ISSN
0305-1870
Abstract
SUMMARY 1. The aim of the present study was to determine whether the vasorelaxant effect of atrial natriuretic peptide (ANP) is, in part, endothelium dependent in humans. 2. We used veno-occlusive plethysmography to measure forearm blood flow (FBF) during intra-arterial infusions of ANP (4, 8, 16, 32 pmol/min per dL forearm tissue volume) before and after the inhibition of nitric oxide (NO) synthesis by NG-monomethyl-L-arginine (L-NMMA; 100 mol) in seven normal healthy subjects. [ABSTRACT FROM AUTHOR]