부산대학교 도서관

We report the case of a 73-year-old female who presented skin necrosis at enoxaparin injection sites after 11 days of treatment. We diagnosed enoxaparin-induced skin necrosis on clinical grounds, as the patient declined biopsy. Fondaparinux was substituted for the enoxaparin, and the lesions were managed conservatively. At follow-up the necrotic lesions had healed to a large degree. This case is uncommon in that laboratory findings excluded the presence of heparin-induced thrombocytopenia (HIT), and therefore the skin necrosis should be attributed to other mechanisms, such as type III hypersensitivity with vasculitis, or repeated local trauma and hemorrhage. [ABSTRACT FROM AUTHOR]