학술논문
New Insights into the High-Density Lipoprotein Dilemma.
Document Type
Article
Author
Source
Subject
*CARDIOVASCULAR diseases risk factors
*HIGH density lipoproteins
*CARDIOTONIC agents
*INSULIN resistance
*ACETATES
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Language
ISSN
1043-2760
Abstract
Although high-density lipoprotein-cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD), efforts to reduce CVD risk by raising HDL-C have not been uniformly successful. Many studies have shown that alcohol consumption, that increases plasma HDL-C concentration, reduces CVD incidence. However, recent genetic studies in large populations have not only removed HDL-C from the causal link between plasma HDL-C concentration and reduced CVD risk, but also suggest that the association is weak. We propose here that the cardioprotective effects of alcohol are mediated by the interaction of its terminal metabolite, acetate, with the adipocyte free fatty acid receptor 2 (FFAR2), which elicits a profound antilipolytic effect that may increase insulin sensitivity without necessarily raising plasma HDL-C concentration. [ABSTRACT FROM AUTHOR]