학술논문
Small Molecules in the Cone Snail Arsenal.
Document Type
Article
Author
Source
Subject
*CONUS
*SMALL molecules
*VENOM
*PEPTIDES
*CONOTOXINS
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*
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Language
ISSN
1523-7060
Abstract
Conesnails are renowned for producing peptide-based venom, containingconopeptides and conotoxins, to capture their prey. A novel small-moleculeguanine derivative with unprecedented features, genuanine, was isolatedfrom the venom of two cone snail species. Genuanine causes paralysisin mice, indicating that small molecules and not just polypeptidesmay contribute to the activity of cone snail venom. [ABSTRACT FROM AUTHOR]