학술논문
RNA-Binding Protein Hoip Accelerates PolyQ-Induced Neurodegeneration in Drosophila.
Document Type
Article
Author
Source
Subject
*CARRIER proteins
*NUCLEIC acids
*RNA
*BIOLOGICAL transport
*PROTEIN binding
*DROSOPHILA
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Language
ISSN
0916-8451
Abstract
The article focuses on the scientific concept of abnormal polyglutamine (polyQ) expansion in the N-terminal domain of the human androgen receptor (hAR). It is known to cause spinobulbar muscular atrophy (SBMA), a hereditary human neurodegenerative disorder. With this, experts explore the molecular mechanisms of neurodegeneration in SBMA. They also genetically screened modulators of neurodegeneration in a Drosophila SBMA experimental model system.