학술논문
Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma.
Document Type
Article
Author
Source
Subject
*TUMOR suppressor genes
*HAIR follicles
*SQUAMOUS cell carcinoma
*LABORATORY mice
*GENETIC mutation
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Language
ISSN
0906-6705
Abstract
The article presents a study on the contribution of tumor suppressor identity to the heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma (SCC). Topics mentioned include the tendency of hair follicle stem cells (HFSC) as cells of origin for SCC, use of mice transgenic for lox-stop-lox-KrasG12D mutation, and the ability of the HSFC to drive various SCC phenotypes that associate with the type of tumor suppressor deleted.