학술논문
Development of Ga ethyl cysteinate dimer for PET studies.
Document Type
Article
Author
Source
Subject
*RADIOACTIVE substances
*RADIOACTIVE wastes
*HAZARDOUS wastes
*ANALYTICAL radiochemistry
*NUCLEAR chemistry
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Language
ISSN
0236-5731
Abstract
In this work development of Ga-ethyl cysteinate dimer (Ga-ECD) a Ga tracer for possible cerebral blood flow based on Tc ECD homolog is reported. Ga-ECD was prepared using generator-based GaCl and ECD at optimized conditions. Quality control, stability, partition co-efficient and the biodistribution of the tracer (by tissue counting and PET/CT in rats) was studied. Significant metabolism of the lipophilic tracer into water soluble metabolite(s) led to urinary excretion of the tracer, un-comparable to that of homologous Tc-compound. Cardiac uptake of the complex suggests formation of a possible lipophil cationic complex and/or metabolite. [ABSTRACT FROM AUTHOR]