부산대학교 도서관

For blood stream infections caused by MDR I A. baumannii i , successful treatment using amoxicillin/clavulanate, meropenem, and amikacin was achieved. B Dear Editor: b I Acinetobacter baumannii i has been defined by the World Health Organization as a critical pathogen in severely ill patients admitted to intensive care units (ICUs) and neonatal ICUs (NICUs) worldwide.[1] This pathogen is known as an opportunistic pathogen that can cause serious infections to hospitalized patients, such as blood stream infections, chest infections, wound infections, and ventilator-associated pneumonia.[2] I A. baumannii i can survive in the environment,[3] and several risk factors are attributed to the colonization and infection of I A. baumannii i , these factors include underlying diseases, ICU stay, long hospitalization, use of broad spectrum antibiotics, catheterization, and mechanical ventilation.[1] Antimicrobial drug resistance in I A. baumannii i has been reported worldwide, particularly carbapenem-resistant strains, which considerably limits the range of therapeutic alternatives available due to the different mechanisms used by this pathogen to resist antibiotics, most importantly by enzymatic hydrolysis mediated by carbapenem hydrolyzing class D -lactamases (CHCD): I bla i SB OXA-23-like sb , I bla i SB OXA-24-like sb , I bla i SB OXA-51-like sb , I bla i SB OXA-58-like sb , I bla i SB OXA-104 sb , I bla i SB OXA-143 sb , I bla i SB OXA-164 sb , and I bla i SB OXA-182. sb [4],[5] It is increasingly reported in Europe, Africa, South America, Asia, and Oceania. [Extracted from the article]