학술논문
Variant acute promyelocytic leukaemia with novel NAB2::RARA fusion shows clinical all‐trans retinoic acid and arsenic trioxide sensitivity.
Document Type
Article
Author
Source
Subject
*ACUTE promyelocytic leukemia
*TRETINOIN
*REVERSE transcriptase polymerase chain reaction
*CHRONIC leukemia
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Language
ISSN
0007-1048
Abstract
Variant acute promyelocytic leukaemia with novel NAB2::RARA fusion shows clinical all-trans retinoic acid and arsenic trioxide sensitivity Acute promyelocytic leukaemia (APL) is characterised by reciprocal translocation between the promyelocytic leukaemia ( I PML i ) gene at chromosome 15q24 and the retinoic acid receptor alpha ( I RARA i ) gene at chromosome 17q21. (E) Metaphase FISH using PML:RARA dual fusion translocation probe (Metasystems), which is negative for PML:RARA fusion but displays 3 RARA (green) signals, indicating the presence of a variant RARA translocation. [Extracted from the article]