학술논문
Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone.
Document Type
Article
Author
Source
Subject
*PROSTACYCLIN
*CELLULAR signal transduction
*SCLEROSTIN
*OSTEOCYTES
*KNOCKOUT mice
*CELL differentiation
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Language
ISSN
0006-291X
Abstract
Highlights: [•] Prostacyclin is increased in bone and osteocytes from sclerostin knockout mice. [•] Prostacyclin enhances differentiation and matrix mineralization of osteoblasts. [•] Increased osteocyte prostacyclin associates with increased β-catenin activity. [•] Blockade of Wnt signaling reduces prostacyclin production in osteocytes. [ABSTRACT FROM AUTHOR]