학술논문
Airway epithelial cell cilia transcriptomic dysregulation is associated with the inflammatory phenotype in asthma.
Document Type
Article
Author
Source
Subject
*EPITHELIAL cells
*ASTHMA
*CILIA & ciliary motion
*ACADEMIC medical centers
*PHENOTYPES
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Language
ISSN
0105-4538
Abstract
This article discusses a study that examines the relationship between cilia dysregulation and asthma phenotypes and endotypes. The researchers analyzed the transcriptomic signature of cilia-associated genes in the bronchial airway epithelial cells of patients with asthma and healthy individuals. The results showed that patients with high cilia dysregulation had severe asthma characteristics, including high total IgE, eosinophil counts, and low FEV1. The study suggests that dysregulation of cilia may contribute to inflammation and epithelial remodeling in asthma. Further research is needed to fully understand the implications of these findings. [Extracted from the article]