학술논문
Polymorphism in IFI16 affects CD4+ T-cell counts in HIV-1 infection.
Document Type
Article
Author
Source
Subject
*HIV infections
*GENETIC polymorphisms
*T cells
*DISEASE progression
*MORTALITY
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Language
ISSN
1744-3121
Abstract
Interferon- γ-inducible protein 16 ( IFI16) plays a pivotal role in the death of bystander CD4+ T-cells. Here, we demonstrate that SNP rs1417806 in IFI16 is associated with CD4+ T-cell counts at set point and HIV-1 disease progression, indicating that IFI16 affects HIV-1 pathogenesis especially during the early phase of infection. [ABSTRACT FROM AUTHOR]