학술논문
Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients.
Document Type
Article
Author
Traut, Caroline C; Jones, Joyce L; Sanders, Renata A; Clark, Laura R; Hamill, Matthew M; Stavrakis, Georgia; Sop, Joel; Beckey, Tyler P; Keller, Sara C; Gilliams, Elizabeth A; Cochran, Willa V; Laeyendecker, Oliver; Manabe, Yukari C; Mostafa, Heba H; Thomas, David L; Hansoti, Bhakti; Gebo, Kelly A; Blankson, Joel N
Source
Subject
*MONKEYPOX
*T cells
*VACCINIA
*HIV
*IMMUNOSUPPRESSIVE agents
*
*
*
*
Language
ISSN
0022-1899
Abstract
Orthopoxvirus-specific T-cell responses were analyzed in 10 patients who had recovered from Mpox including 7 people with human immunodeficiency virus (PWH). Eight participants had detectable virus-specific T-cell responses, including a PWH who was not on antiretroviral therapy and a PWH on immunosuppressive therapy. These 2 participants had robust polyfunctional CD4+ T-cell responses to peptides from the 121L vaccinia virus (VACV) protein. T-cells from 4 of 5 HLA-A2–positive participants targeted at least 1 previously described HLA-A2–restricted VACV epitope, including an epitope targeted in 2 participants. These results advance our understanding of immunity in convalescent Mpox patients. [ABSTRACT FROM AUTHOR]