학술논문
Aspirin-induced apoptosis of yeast cells is associated with mitochondrial superoxide radical accumulation and NAD( P) H oxidation.
Document Type
Article
Source
Subject
*PHYSIOLOGICAL effects of aspirin
*APOPTOSIS
*SUPEROXIDE dismutase
*BIOACCUMULATION
*NICOTINAMIDE adenine dinucleotide phosphate
*SCIENTIFIC observation
*YEAST
*CELL growth
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Language
ISSN
1567-1356
Abstract
In previous studies, we observed that aspirin, a promising cancer-preventive agent, induces apoptosis in mitochondrial manganese superoxide dismutase ( Mn SOD)-deficient Saccharomyces cerevisiae cells grown aerobically in ethanol medium. In this study, we show that aspirin-induced apoptosis is associated with a significant increase in mitochondrial and cytosolic [ABSTRACT FROM AUTHOR]