부산대학교 도서관

During a program of investigation on potentially bioactive secondary metabolites from Formosan endemic plant endophytes, an endophytic fungal strain, I Hypoxylon monticulosum i (Xylaraceae), was isolated from the stems of I Litsea akoensis i var I . chitouchiaoensis i (Lauraceae). Our previous investigations of secondary metabolites from the genus I Hypoxylon i have led to the isolation of three new compounds, hypoxyloamide, 8-methoxynaphthalene-1,7-diol, and hypoxylonol, together with seven compounds isolated from nature for the first time, along with 19 known compounds isolated from the culture broth of I Hypoxylon investiens i BCRC 10F0115. Column chromatography (CC): silica gel 60 (70-230 or 230-400 mesh, Merck) and spherical C18 100A reversed phase silica gel (RP-18) (particle size: 20-40 m) (Silicycle). The BuOH-soluble fraction (34.4 g) was subjected to silica gel CC eluting with CH SB 2 sb Cl SB 2 sb -MeOH (19:1), gradually increasing the polarity with MeOH to furnish five fractions (Frs. [Extracted from the article]