학술논문

Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering.
Document Type
Article
Source
International Journal of Polymeric Materials & Polymeric Biomaterials. 2019, Vol. 68 Issue 5, p243-255. 13p.
Subject
*BIOMIMETIC materials
*BLOOD vessels
*TISSUE engineering
*ETHYLCELLULOSE
*FOURIER transform infrared spectroscopy
*BIOPOLYMERS
Language
ISSN
0091-4037
Abstract
A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability. [ABSTRACT FROM AUTHOR]