소장자료
| LDR | 02120cam a2200313 a 4500 | ||
| 001 | 0093771745▲ | ||
| 005 | 20180520001013▲ | ||
| 008 | 161201s2017 njua b 001 0 eng c▲ | ||
| 010 | ▼a2016055388▲ | ||
| 020 | ▼a9781118916698 (cloth)▲ | ||
| 035 | ▼a(KERIS)REF000018228374▲ | ||
| 040 | ▼aDNLM/DLC▼cDLC▼d221016▲ | ||
| 042 | ▼apcc▲ | ||
| 050 | 0 | 0 | ▼aRS403▲ |
| 060 | 1 | 0 | ▼aQV 38▲ |
| 082 | 0 | 0 | ▼a615.1/9▼223▲ |
| 090 | ▼a615.19▼bE37o▲ | ||
| 100 | 1 | ▼aEl-Kattan, Ayman F.▲ | |
| 245 | 1 | 0 | ▼aOral bioavailability assessment :▼bbasics and strategies for drug discovery and development /▼cAyman F. El-Kattan.▲ |
| 260 | ▼aHoboken, NJ :▼bJohn Wiley & Sons Inc.,▼c2017.▲ | ||
| 300 | ▼aviii, 436 p. :▼bill. ;▼c24 cm.▲ | ||
| 490 | 0 | ▼aWiley series on pharmaceutical science and biotechnology: practices, applications and methods▲ | |
| 504 | ▼aIncludes bibliographical references and index.▲ | ||
| 505 | 0 | ▼aDrug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.▲ | |
| 650 | 1 | 2 | ▼aBiological Availability.▲ |
| 650 | 2 | 2 | ▼aDrug Evaluation, Preclinical.▲ |
| 650 | 2 | 2 | ▼aToxicokinetics.▲ |
| 650 | 2 | 2 | ▼aAdministration, Oral.▲ |
| 999 | ▼a김진영▼c김미선▲ |
Oral bioavailability assessment :basics and strategies for drug discovery and development
자료유형
국외단행본
서명/책임사항
Oral bioavailability assessment : basics and strategies for drug discovery and development / Ayman F. El-Kattan.
발행사항
Hoboken, NJ : John Wiley & Sons Inc. , 2017.
형태사항
viii, 436 p. : ill. ; 24 cm.
서지주기
Includes bibliographical references and index.
내용주기
Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.
ISBN
9781118916698 (cloth)
청구기호
615.19 E37o
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