소장자료
LDR | 07783cam a2200000 a | ||
001 | 0100524062▲ | ||
003 | OCoLC▲ | ||
005 | 20210909095828▲ | ||
007 | ta▲ | ||
008 | 170404t20172017enka b 001 0 eng c▲ | ||
020 | ▼a9781785481451 (hbk.)▲ | ||
020 | ▼a1785481452 (hbk.)▲ | ||
035 | ▼a(OCoLC)955541151▼z(OCoLC)956350579▲ | ||
040 | ▼aNLM▼beng▼cNLM▼dBTCTA▼dPAU▼dUNL▼dYDXCP▼dOCLCO▼dNLM▼dU3G▼dOCLCF▼dOCLCQ▼dOCLCO▼dOCLCA▼d221016▲ | ||
082 | 0 | 4 | ▼a615.19▼223▲ |
090 | ▼a615.19▼bL618n▲ | ||
100 | 1 | ▼aLe Roux, Murielr.▲ | |
245 | 1 | 0 | ▼aNavelbine and Taxotere :▼bhistories of sciences /▼cMuriel Le Roux, Françoise Guéritte.▲ |
260 | ▼aLondon :▼bISTE Press ;▼aOxford, UK :▼bElsevier, ▼c2017.▲ | ||
300 | ▼axiii, 246 p. :▼bill. ;▼c24 cm.▲ | ||
490 | 0 | ▼aMolecular, green, medicinal, and pharmacological chemistry series▲ | |
504 | ▼aIncludes bibliographical references and index.▲ | ||
505 | 0 | 0 | ▼gMachine generated contents note:▼gch. 1▼tCo-constructing the Past for a History of the Chemistry of Natural Substances --▼g1.1.▼tA convergence --▼g1.2.▼t"A small world" --▼g1.3.▼tIncomplete sources on the history of the chemistry of natural substances? --▼g1.4.▼tAn original way of telling the history of chemistry: "a compagnonnage" --▼gch. 2▼tThe Institut de chimie des substances naturelles of the CNRS (1955 -- 2000): Emblematic of an Evolving Area of Research? --▼g2.1.▼tResearch in France and the CNRS: ambivalent sentiments? --▼g2.1.1.▼tFrom the creation of the CNRS in 1939 to its first reorganization in 1959 --▼g2.1.2.▼tFrom pragmatism to 1979 reform --▼g2.1.3.▼tFrom the "Assises de la recherche" of 1981 -- 1982 to the 2000s --▼g2.2.▼tChemistry at the CNRS --▼g2.3.▼tThe ICSN: a place for discovery (from 1955 to the 2000s) --▼g2.4.▼t"Science is a social and political act": Pierre Potier (1934 -- 2006) --▼g2.4.1.▼tLearning from research --▼g2.4.2.▼tResearch is a resource --▼g2.4.3.▼tIntuition and daring in service of a cause: the discoveries of Navelbine® and Taxotere® --▼gch. 3▼tFrom Catharanthus roseus Alkaloids to the Discovery of Vinorelbine (Navelbine®) --▼g3.1.▼tCatharanthus roseus: botany, herbaria, empirical medicine --▼g3.1.1.▼tCreation of the genus Catharanthus --▼g3.1.2.▼tThe earliest samples and herbaria of C. roseus --▼g3.1.3.▼tFrom the use of C. roseus in popular medicine for its antidiabetic properties to the discovery of cytotoxic properties --▼g3.2.▼tBisindolic alkaloids of Catharanthus roseus (1950s -- 60s) --▼g3.2.1.▼tFrom the first chemical studies to the structural characterization of vinblastine and vincristine --▼g3.2.2.▼tVinblastine and vincristine: the first plant-based anti-cancer medications --▼g3.3.▼tStudies conducted at the ICSN: modified Polonovski reaction and chemical studies of Catharanthus (1960s -- 1970s) --▼g3.3.1.▼tThe modified Polonovski reaction or Polonovski-Potier reaction --▼g3.3.2.▼tFirst chemical studies of Catharanthus species at the ICSN --▼g3.4.▼tStudies conducted at the ICSN: semisynthesis of alkaloids such as vinblastine -- biological activity and biosynthesis (1970s -- 1980s) --▼g3.4.1.▼tState of the art: first semisynthesis leading to analogs of vinblastine with "unnatural" 18'r configuration --▼g3.4.2.▼tFirst semisynthesis of anhydrovinblastine -- an analog of vinblastine with the natural configuration (18's) --▼g3.4.3.▼tMechanism of anhydrovinblastine formation --▼g3.4.4.▼tDetermination of the configuration at C-18 (18's versus 18'r): electronic circular dichroism --▼g3.4.5.▼tAntitumoral activity and evaluation with the tubulin test --▼g3.4.6.▼tBiosynthesis of bisindolic alkaloids: anhydrovinblastine is a natural product --▼g3.5.▼tFrom anhydrovinblastine to leurosine, leurosidine, vinblastine and the discovery of vinorelbine --▼g3.5.1.▼tTransformation of anhydrovinblastine into leurosine, leurosidine and vinblastine --▼g3.5.2.▼tDiscovery of 7'-nor-anhydrovinblastine or navelbine and first pharmacological and clinical results --▼g3.5.3.▼tThe search for a new process to synthesize 7'-nor-anhydrovinblastine (vinorelbine) --▼gch. 4▼tFrom the Pacific Yew (Taxus brevifolia) to the English Yew (Taxus baccata): Steps Towards the Discovery of Docetaxel (Taxotere®) --▼g4.1.▼tThe common yew, Taxus baccata --▼g4.1.1.▼tYews, botanies and toxicity --▼g4.1.2.▼tFirst phytochemical studies of the common yew (T. baccata) and other species of Taxus --▼g4.2.▼tFrom the Pacific yew, Taxus brevifolia, to Taxol®, an anti-cancer molecule with a new mechanism of action --▼g4.2.1.▼tDiscovery of taxol, cytotoxic diterpene isolated from the Pacific yew --▼g4.2.2.▼tTaxol: a new mechanism of action and difficulties encountered during its development --▼g4.3.▼tPhytochemical studies carried out at the ICSN: discovery of 10-deacetylbaccatin III in the natural state (1980s) --▼g4.3.1.▼tExtraction and purification of T. baccata, monitoring the activity on tubulin --▼g4.3.2.▼tIsolation of 10-deacetylbaccatin III --▼g4.3.3.▼tIsolation of other taxanes and biological activity on tubulin --▼g4.3.4.▼tStudy of the pharmacological properties of taxol at the ICSN and at the Faculte de Pharmacie in Grenoble --▼g4.4.▼tSteps toward the first semisynthesis of 10-deacetyltaxol, of taxol and discovery of a highly active analog by the aminohydroxylation reaction --▼g4.4.1.▼tChemical studies of 10-deacetylbaccatin III --▼g4.4.2.▼tStudies on the esterification of 7, 10-ditroc-10-deacetylbaccatin III. Semisynthesis of cinnamic ester of 10-deacetylbaccatin III --▼g4.4.3.▼tFunctionalization of the cinnamic ester double bond: discovery of a compound (Oxy 1) more active than taxol --▼g4.4.4.▼tFirst semisynthesis of 10-deacetyltaxol and taxol --▼g4.4.5.▼tEarliest pharmacological studies of Oxy 1 (56 976 R.P.) --▼g4.5.▼tSecond semisynthesis of taxol by a convergent process --▼g4.5.1.▼tFirst convergent semisynthesis of taxol --▼g4.5.2.▼tOther convergent semisynthesis and semisynthetic version of taxol approved by the FDA --▼g4.6.▼tA step toward the development of 56 976 R.P., which was to become Taxotere® --▼g4.6.1.▼tLarge-scale extraction and purification of 10-deacetylbaccatin III --▼g4.6.2.▼tSteps toward the convergent synthesis of 56 976 R.P. --▼g4.6.3.▼tFrom pharmacological and clinical properties to market authorization for Taxotere® (56 976 R.P.).▲ |
650 | 0 | ▼aVinorelbine▼xDevelopment.▲ | |
650 | 0 | ▼aDocetaxel▼xDevelopment.▲ | |
650 | 0 | ▼aAntineoplastic agents▼xDevelopment.▲ | |
650 | 0 | ▼aAntineoplastic agents▼xDesign.▲ | |
650 | 0 | ▼aDrug development▼zFrance.▲ | |
700 | 1 | ▼aGuéritte, Françoise.▲ |
Navelbine and Taxotere :histories of sciences
자료유형
국외단행본
서명/책임사항
Navelbine and Taxotere : histories of sciences / Muriel Le Roux, Françoise Guéritte.
발행사항
London : ISTE Press ; Oxford, UK : Elsevier , 2017.
형태사항
xiii, 246 p. : ill. ; 24 cm.
서지주기
Includes bibliographical references and index.
내용주기
Machine generated contents note : ch. 1 Co-constructing the Past for a History of the Chemistry of Natural Substances -- 1.1. A convergence -- 1.2. "A small world" -- 1.3. Incomplete sources on the history of the chemistry of natural substances? -- 1.4. An original way of telling the history of chemistry: "a compagnonnage" -- ch. 2 The Institut de chimie des substances naturelles of the CNRS (1955 -- 2000): Emblematic of an Evolving Area of Research? -- 2.1. Research in France and the CNRS: ambivalent sentiments? -- 2.1.1. From the creation of the CNRS in 1939 to its first reorganization in 1959 -- 2.1.2. From pragmatism to 1979 reform -- 2.1.3. From the "Assises de la recherche" of 1981 -- 1982 to the 2000s -- 2.2. Chemistry at the CNRS -- 2.3. The ICSN: a place for discovery (from 1955 to the 2000s) -- 2.4. "Science is a social and political act": Pierre Potier (1934 -- 2006) -- 2.4.1. Learning from research -- 2.4.2. Research is a resource -- 2.4.3. Intuition and daring in service of a cause: the discoveries of Navelbine® and Taxotere® -- ch. 3 From Catharanthus roseus Alkaloids to the Discovery of Vinorelbine (Navelbine®) -- 3.1. Catharanthus roseus: botany, herbaria, empirical medicine -- 3.1.1. Creation of the genus Catharanthus -- 3.1.2. The earliest samples and herbaria of C. roseus -- 3.1.3. From the use of C. roseus in popular medicine for its antidiabetic properties to the discovery of cytotoxic properties -- 3.2. Bisindolic alkaloids of Catharanthus roseus (1950s -- 60s) -- 3.2.1. From the first chemical studies to the structural characterization of vinblastine and vincristine -- 3.2.2. Vinblastine and vincristine: the first plant-based anti-cancer medications -- 3.3. Studies conducted at the ICSN: modified Polonovski reaction and chemical studies of Catharanthus (1960s -- 1970s) -- 3.3.1. The modified Polonovski reaction or Polonovski-Potier reaction -- 3.3.2. First chemical studies of Catharanthus species at the ICSN -- 3.4. Studies conducted at the ICSN: semisynthesis of alkaloids such as vinblastine -- biological activity and biosynthesis (1970s -- 1980s) -- 3.4.1. State of the art: first semisynthesis leading to analogs of vinblastine with "unnatural" 18'r configuration -- 3.4.2. First semisynthesis of anhydrovinblastine -- an analog of vinblastine with the natural configuration (18's) -- 3.4.3. Mechanism of anhydrovinblastine formation -- 3.4.4. Determination of the configuration at C-18 (18's versus 18'r): electronic circular dichroism -- 3.4.5. Antitumoral activity and evaluation with the tubulin test -- 3.4.6. Biosynthesis of bisindolic alkaloids: anhydrovinblastine is a natural product -- 3.5. From anhydrovinblastine to leurosine, leurosidine, vinblastine and the discovery of vinorelbine -- 3.5.1. Transformation of anhydrovinblastine into leurosine, leurosidine and vinblastine -- 3.5.2. Discovery of 7'-nor-anhydrovinblastine or navelbine and first pharmacological and clinical results -- 3.5.3. The search for a new process to synthesize 7'-nor-anhydrovinblastine (vinorelbine) -- ch. 4 From the Pacific Yew (Taxus brevifolia) to the English Yew (Taxus baccata): Steps Towards the Discovery of Docetaxel (Taxotere®) -- 4.1. The common yew, Taxus baccata -- 4.1.1. Yews, botanies and toxicity -- 4.1.2. First phytochemical studies of the common yew (T. baccata) and other species of Taxus -- 4.2. From the Pacific yew, Taxus brevifolia, to Taxol®, an anti-cancer molecule with a new mechanism of action -- 4.2.1. Discovery of taxol, cytotoxic diterpene isolated from the Pacific yew -- 4.2.2. Taxol: a new mechanism of action and difficulties encountered during its development -- 4.3. Phytochemical studies carried out at the ICSN: discovery of 10-deacetylbaccatin III in the natural state (1980s) -- 4.3.1. Extraction and purification of T. baccata, monitoring the activity on tubulin -- 4.3.2. Isolation of 10-deacetylbaccatin III -- 4.3.3. Isolation of other taxanes and biological activity on tubulin -- 4.3.4. Study of the pharmacological properties of taxol at the ICSN and at the Faculte de Pharmacie in Grenoble -- 4.4. Steps toward the first semisynthesis of 10-deacetyltaxol, of taxol and discovery of a highly active analog by the aminohydroxylation reaction -- 4.4.1. Chemical studies of 10-deacetylbaccatin III -- 4.4.2. Studies on the esterification of 7, 10-ditroc-10-deacetylbaccatin III. Semisynthesis of cinnamic ester of 10-deacetylbaccatin III -- 4.4.3. Functionalization of the cinnamic ester double bond: discovery of a compound (Oxy 1) more active than taxol -- 4.4.4. First semisynthesis of 10-deacetyltaxol and taxol -- 4.4.5. Earliest pharmacological studies of Oxy 1 (56 976 R.P.) -- 4.5. Second semisynthesis of taxol by a convergent process -- 4.5.1. First convergent semisynthesis of taxol -- 4.5.2. Other convergent semisynthesis and semisynthetic version of taxol approved by the FDA -- 4.6. A step toward the development of 56 976 R.P., which was to become Taxotere® -- 4.6.1. Large-scale extraction and purification of 10-deacetylbaccatin III -- 4.6.2. Steps toward the convergent synthesis of 56 976 R.P. -- 4.6.3. From pharmacological and clinical properties to market authorization for Taxotere® (56 976 R.P.).
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ISBN
9781785481451 (hbk.) 1785481452 (hbk.)
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615.19 L618n
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